DBL Potassium Dihydrogen Phosphate Dosage/Direction for Use

Dosage: For the treatment of severe hypophosphataemia, the following doses are suggested.
Adults: up to 10 mmol phosphate administered over 12 hours. The dose may be repeated at 12 hour intervals until serum phosphate exceeds 0.3 mmol/L.
Children: 0.15-0.33 mmol/kg administered over 6 hours. The dose may be repeated at 6 hour intervals until serum phosphate exceeds 0.6 mmol/L. The dose should not exceed the maximum recommended adult dose. The rate of infusion should not exceed 0.2 mmol/kg/h.
Method of Administration: DBL Potassium Dihydrogen Phosphate Concentrated Injection is administered by slow intravenous infusion. The injection must be diluted before use.
Dilution: DBL Potassium Dihydrogen Phosphate Concentrated Injection must be diluted before use. The drug can be given in 0.9% sodium chloride or 5% glucose solution. It should be administered by slow infusion to avoid phosphate intoxication.
Monitoring: Serum sodium, potassium, phosphate and calcium concentrations and renal function should be monitored every 12 to 24 hours during therapy.
Conversion to oral phosphate therapy should occur as soon as possible.
Dosage Adjustments: Renal Impairment: dose should be reduced. Use of phosphates in severe renal impairment is contraindicated (see Contraindications).